3 Best Medications to Stop Drinking

Discover the best medications to stop drinking and take control of your sobriety journey. Find effective solutions with professional guidance.

Leora BH Staff
December 15, 2023

Medications to Aid in Sobriety

When it comes to overcoming alcohol use disorder, medications can play a crucial role in the treatment process. Understanding the role of medications and their benefits in stopping drinking is essential for individuals seeking sobriety.

Understanding the Role of Medications in Alcohol Use Disorder Treatment

Medications are an integral part of comprehensive treatment for alcohol use disorder. They are designed to help individuals reduce or stop drinking, manage withdrawal symptoms, and prevent relapse. While medications alone may not provide a complete solution, they can significantly enhance the effectiveness of therapy and support.

Medications work by targeting various aspects of alcohol dependence, including reducing cravings, altering brain chemistry, and blocking the pleasurable effects of alcohol. They can help individuals regain control over their drinking habits and facilitate the recovery process.

The Benefits of Medications in Stopping Drinking

The benefits of medications for stopping drinking are multi-fold. They can:

  • Reduce cravings: Medications can help suppress the intense urge to drink, making it easier for individuals to resist the temptation.
  • Alleviate withdrawal symptoms: Withdrawal symptoms can be severe and even life-threatening for those with alcohol dependence. Medications can help manage these symptoms, ensuring a safer and more comfortable detoxification process.
  • Aid in relapse prevention: By targeting the brain's reward system, medications can help individuals resist the pleasurable effects of alcohol, making relapse less likely.
  • Enhance treatment outcomes: When used in combination with therapy and support, medications can significantly improve treatment outcomes and long-term sobriety rates.

It's important to note that the effectiveness of medications may vary from person to person. Factors such as individual physiology, severity of alcohol dependence, and adherence to treatment play a role in determining the overall success of medication-assisted treatment.

FDA-Approved Medications for Alcohol Use Disorder

When it comes to treating alcohol use disorder (AUD), several medications have been approved by the U.S. Food and Drug Administration (FDA) to aid individuals in their journey towards sobriety. These medications, when used in conjunction with therapy and support, can be effective tools in helping individuals reduce their alcohol consumption or achieve complete abstinence. Let's explore three FDA-approved medications for alcohol use disorder: disulfiram, naltrexone, and acamprosate.


Disulfiram works by causing unpleasant physical reactions when alcohol is consumed. It blocks an enzyme called aldehyde dehydrogenase, which plays a role in breaking down alcohol in the body. When someone taking disulfiram drinks alcohol, they experience symptoms such as nausea, vomiting, headache, and flushing. This aversion to alcohol can help deter individuals from drinking.


Naltrexone is an opioid receptor antagonist that blocks the effects of endorphins released when alcohol is consumed. By doing so, it helps reduce cravings and the pleasurable effects associated with alcohol. Naltrexone can be taken orally in the form of a tablet or as an extended-release injectable. It is important to note that naltrexone should only be used after the individual has completely detoxed from alcohol and is no longer physically dependent on it.


Acamprosate is thought to work by stabilizing the chemical balance in the brain that is disrupted by long-term alcohol use. It is believed to help reduce cravings and withdrawal symptoms, making it easier for individuals to abstain from alcohol. Acamprosate is typically taken orally in tablet form and is most effective when used as part of a comprehensive treatment plan that includes therapy and support.

To determine the most suitable medication for an individual with alcohol use disorder, it is crucial to consult with a healthcare provider who specializes in addiction medicine. They will evaluate the individual's specific needs, medical history, and other factors to create an individualized treatment plan. It's worth noting that these medications may not be appropriate or effective for everyone, and the decision to use them should be made in collaboration with a healthcare professional.

How These Medications Work

To effectively combat alcohol use disorder and support the journey to sobriety, various medications have been approved by the FDA. Understanding how these medications work is essential in comprehending their role in alcohol use disorder treatment. Let's explore the mechanisms of action for three commonly prescribed medications: disulfiram, naltrexone, and acamprosate.

Disulfiram's Mechanism of Action

Disulfiram works by creating an unpleasant reaction when alcohol is consumed. It inhibits the enzyme acetaldehyde dehydrogenase, which is responsible for breaking down alcohol in the body. As a result, when a person taking disulfiram consumes alcohol, they may experience severe discomfort, including nausea, vomiting, headache, and rapid heartbeat. This aversion reaction serves as a deterrent to drinking alcohol.

Naltrexone's Mechanism of Action

Naltrexone operates by blocking the effects of opioids in the brain, which helps reduce alcohol cravings. It works on the opioid receptors, preventing the release of endorphins and the reinforcing effects of alcohol. By reducing the pleasurable sensations associated with alcohol consumption, naltrexone helps individuals maintain abstinence and decrease the desire to drink. It is available in both oral and injectable forms, providing flexibility in treatment options.

Acamprosate's Mechanism of Action

Acamprosate is thought to work by stabilizing the chemical balance in the brain that has been disrupted by long-term alcohol use. It modulates the activity of certain neurotransmitters, such as gamma-aminobutyric acid (GABA) and glutamate, which play a role in regulating brain function. By restoring this balance, acamprosate helps reduce cravings and withdrawal symptoms, making it easier for individuals to maintain abstinence from alcohol.

Understanding the mechanisms of action behind these medications provides insights into how they assist individuals in their journey toward sobriety. It's important to consult a healthcare provider who can evaluate your specific needs and recommend the most appropriate medication based on your unique circumstances. Medications like disulfiram, naltrexone, and acamprosate are often used in conjunction with behavioral therapies and support programs to maximize the chances of successful treatment outcomes. For a comprehensive treatment plan, it's crucial to integrate medications with therapies tailored to individual needs.

Effectiveness and Considerations

When considering medications to help reduce alcohol consumption, it's important to understand the efficacy of these medications and the factors to consider when choosing which one may be most suitable for an individual.

Efficacy of Medications in Reducing Alcohol Consumption

Medications approved by the FDA for the treatment of alcohol use disorder have shown effectiveness in reducing alcohol consumption and promoting sobriety. These medications work by targeting different aspects of alcohol dependence, such as reducing cravings, blocking the pleasurable effects of alcohol, and minimizing the discomfort associated with alcohol withdrawal.

Medication Effectiveness

  • Disulfiram: Helps deter drinking by causing unpleasant reactions, such as nausea and flushing, when alcohol is consumed.
  • Naltrexone: Reduces alcohol cravings and blocks the pleasurable effects of alcohol.
  • Acamprosate: Helps maintain abstinence by reducing post-acute withdrawal symptoms and cravings.

It's important to note that the effectiveness of these medications can vary from person to person, and individual responses may differ. It is recommended to consult with a healthcare provider to determine the most suitable medication based on an individual's specific needs and medical history.

Factors to Consider When Choosing Medications

Several factors should be taken into consideration when choosing a medication to help stop drinking. These factors can include:

  1. Individual Needs: Different medications may be more effective for certain individuals based on their unique circumstances, medical history, and preferences. Consulting with a healthcare provider can help determine which medication aligns best with an individual's needs.
  2. Side Effects: Each medication carries the potential for side effects. Understanding the potential side effects and discussing them with a healthcare provider can help weigh the benefits and risks of each medication.
  3. Interactions: It's important to consider any potential interactions between the medication and other medications or substances an individual may be taking. Informing the healthcare provider about all current medications and substances being used will help avoid any adverse interactions.
  4. Treatment Plan: Medications are often used in combination with other forms of treatment, such as therapy and support groups. Considering how the medication fits into an overall treatment plan is essential for comprehensive and effective care. Integrating medications with behavioral therapies is a common approach to treating alcohol use disorder.

By understanding the effectiveness of medications in reducing alcohol consumption and considering individual factors, individuals can make informed decisions with the guidance of healthcare professionals. It's important to remember that medications alone may not be sufficient for long-term recovery, and a comprehensive treatment plan that addresses the physical, psychological, and social aspects of alcohol use disorder is crucial.

Combining Medications with Therapy and Support

A comprehensive approach to treating alcohol use disorder (AUD) involves more than just medication. Combining medications with therapy and support can significantly enhance the effectiveness of treatment and increase the chances of long-term sobriety. In this section, we will explore the importance of comprehensive treatment and the integration of medications with behavioral therapies.

The Importance of Comprehensive Treatment

Treating AUD requires a holistic approach that addresses both the physiological and psychological aspects of addiction. Medications play a crucial role in helping individuals reduce alcohol consumption and maintain sobriety. However, they work best when combined with therapy and support.

Comprehensive treatment may include individual counseling, group therapy, support groups, and other evidence-based behavioral therapies. These therapeutic interventions provide individuals with the necessary tools to cope with triggers, manage cravings, and develop healthy coping mechanisms. Moreover, therapy can help individuals address underlying psychological issues that may contribute to alcohol use.

By combining medications with therapy, individuals can benefit from a multi-faceted approach that targets various aspects of AUD. This comprehensive treatment approach increases the likelihood of successful recovery and long-term sobriety.

Integrating Medications with Behavioral Therapies

Integrating medications with behavioral therapies is a powerful combination in the treatment of AUD. Medications can help reduce alcohol cravings and withdrawal symptoms, while behavioral therapies provide individuals with the skills and support needed to maintain abstinence.

During therapy sessions, individuals can explore the underlying reasons for their alcohol use, identify triggers and high-risk situations, and develop strategies to overcome challenges. Therapists can utilize various evidence-based approaches, such as cognitive-behavioral therapy (CBT), motivational interviewing (MI), and contingency management (CM), to address specific needs and goals.

Additionally, support groups like Alcoholics Anonymous (AA) or SMART Recovery can offer a sense of community and peer support. These groups provide a safe space for individuals to share their experiences, learn from others, and receive ongoing support throughout their recovery journey.

Integrating medications with behavioral therapies allows individuals to address the physical and psychological aspects of AUD simultaneously. By combining pharmacological interventions with therapeutic approaches, individuals can enhance their chances of successful recovery and long-term sobriety.

Remember, it is essential to consult with a healthcare provider or addiction specialist to develop an individualized treatment plan that suits your specific needs. They can guide you in choosing the most appropriate medications and therapy options based on your unique circumstances.

Seeking Professional Guidance

When considering medications to help stop drinking, it is essential to seek professional guidance from a healthcare provider. Consulting with a healthcare provider who specializes in addiction medicine or mental health can provide valuable insights and personalized recommendations to support your journey towards sobriety.

Consultation with a Healthcare Provider

A consultation with a healthcare provider is an important first step in exploring medications for alcohol use disorder. They will assess your individual needs, medical history, and specific circumstances to determine the most appropriate treatment options for you. By discussing your goals, concerns, and any existing health conditions or medications you may be taking, they can tailor the treatment plan to your unique circumstances.

During the consultation, your healthcare provider will conduct a thorough evaluation to assess the severity of your alcohol use disorder and any potential underlying physical or mental health conditions. This evaluation will help guide the selection of medications and determine the appropriate dosage and duration of treatment. They may also discuss the potential side effects and risks associated with the medications to ensure you are well-informed.

Individualized Treatment Plans

Once your healthcare provider has gathered all the necessary information, they will work with you to develop an individualized treatment plan. This plan will outline the specific medications, dosages, and administration instructions that are most suitable for your situation. It may also include additional components such as therapy, counseling, or support groups.

An individualized treatment plan takes into account various factors, including the severity of your alcohol use disorder, your overall health, and your personal preferences. The combination of medications and therapeutic interventions can provide a comprehensive approach to support your journey to sobriety.

Remember, it is crucial to follow your healthcare provider's guidance and instructions throughout the treatment process. By seeking professional guidance, you can receive expert advice and personalized treatment plans that are tailored to your specific needs and circumstances.


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Leora Behavioral Health offers a comprehensive addiction treatment program to help you get your life back on track. Our trained professionals will work with you to develop a personalized treatment plan that meets your unique needs. If you or someone you know is struggling with addiction, reach out to Leora Behavioral Health today.

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